In their recent Environmental Noise Guidelines (ENG) the World Health Organization (WHO) identified several critical health outcomes of environmental noise, among them cardiovascular diseases, annoyance, effects on sleep, cognitive impairment, and hearing impairment/ tinnitus. Aiming at protecting the population from adverse noise effects, the Environmental Noise Directive 2002/49/EC (END) is the main instrument guiding the noise mapping and the development of noise action plans in EU Member States. END Annex III describes methods of the assessment of health impacts (HIA) of noise in terms of the number of highly annoyed and sleep disturbed persons in a given area. A new study commissioned by the European Commission describes a HIA methodology for environmental noise which considers the critical health outcomes as identified in the WHO ENG. In summary, two methods, the assessment of number of people affected by different health outcomes and the environmental burden due to environmental noise in terms of the calculation of disability-adjusted live years (DALY) are described. We present a case study where both HIA methods were applied to the City of Duesseldorf, Germany, in order to describe the status quo of the health impact as well as the health impact of simulated transportation noise interventions.